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- Jonathan Silverman as Barry Thomas
- Helen Slater as Lisa Fredericks
- Nicolas Surovy as Robert Denk
- Robin Bartlett as Anne Jackson
- Jeremy Piven as Howard Richter
- Constance Marie as Joan Zevo
- Glenn Morshower as Detective Cryers
- Martin Landau as Dr. Thadius Moxley
- Paxton Whitehead as Dr. Tiberius Scott
- Cheryl Anderson as Supervisor