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- John Cusack as Mike Enslin
- Samuel L. Jackson as Gerald Olin
- Mary McCormack as Lily Enslin
- Tony Shalhoub as Sam Farrell
- Len Cariou as Mike's Father
- Jasmine Jessica Anthony as Katie Enslin
- Isiah Whitlock, Jr. as Hotel Engineer
- Kim Thomson as Hotel Desk Clerk
- Benny Urquidez as Claw Hammer Maniac
- Andrew-Lee Potts as Mailbox Guy