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- Katherine Heigl as Jane Nichols
- James Marsden as Malcolm Kevin Doyle
- Malin Akerman as Tess Nichols
- Edward Burns as George
- Judy Greer as Casey
- Melora Hardin as Maureen
- Michael Ziegfeld as Khaleel
- Brian Kerwin as Hal Nichols
- Maulik Pancholy as Trent
- David Castro as Pedro
- Krysten Ritter as Gina
- Peyton List as Young Jane Nichols
- Charli Barcena as Young Tess Nichols