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- Bruce Boxleitner as Col. Martin
- Jason London as Aaron Schumacher
- Rachel Miner as Sgt. Hannah
- Vanessa Branch as Claire
- Andrew Sensenig as Dr. Keane
- John Shea as Sam Whitaker
- Jillian Batherson as Gomez
- Lena Clark as Mindy
- Damon Lipari as Kevin
- VyVy Nguyen as Elisia
- Ivan Djurovic as Lady Death
- Tammi Arender as Sharon Solomon
- Jed Maheu as Patient Zero