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- Uma Thurman as Dr. Emmeline "Emma" Lloyd
- Jeffrey Dean Morgan as Patrick Sullivan
- Colin Firth as Richard Braxton
- Isabella Rossellini as Mrs. Greta Bollenbecker
- Keir Dullea as Karl Bollenbecker
- Sam Shepard as Wilder
- Kristina Klebe as Katerina Bollenbecker
- Lindsay Sloane as Marcy
- Justina Machado as Sofia
- Sarita Choudhury as Sunday
- Brooke Adams as Carolyn
- Michael Mosley as Declan
- Ajay Naidu as Deep