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- Melai Cantiveros as Pura Buraot/Pureza Mayriles/Sor. Eyes
- Jason Francisco as Ruben Padilla/Sor. Throat
- Joem Bascon as Gerald Tanderson
- Martin del Rosario as Ulam Buraot/ Ulysses Buraot
- Bianca Manalo as Daniella Fabella de la Bamba
- Gina Pareno as Mother Baby/Mother Greedy
- Nico Antonio as Hipon
- Bekimon as Zeppy
- Bella Flores as Sr. Pepa Papparazzi
- Pokwang as Sr. Purisima