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- Morgan Freeman as Alex Cross
- Monica Potter as Jezzie Flannigan
- Michael Wincott as Gary Soneji
- Dylan Baker as Ollie McArthur
- Mika Boorem as Megan Rose
- Billy Burke as Ben Devine
- Anton Yelchin as Dimitri Starodubov
- Jay O. Sanders as Kyle Craig
- Michael Moriarty as Senator Hank Rose
- Penelope Ann Miller as Elizabeth Rose
- Anna Maria Horsford as Vickie