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- Freddie Highmore as George Zinavoy
- Emma Roberts as Sally Howe
- Michael Angarano as Dustin Mason
- Alicia Silverstone as Ms. Herman
- Rita Wilson as Vivian Sargent
- Blair Underwood as Principal Bill Martinson
- Elizabeth Reaser as Charlotte Howe
- Sam Robards as Jack Sargent
- Marcus Carl Franklin as Will Sharpe
- Sasha Spielberg as Zoe Rubenstein
- Jarlath Conroy as Harris McElroy