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- Meryl Streep as Violet Weston
- Julia Roberts as Barbara Weston-Fordham
- Ewan McGregor as Bill Fordham
- Chris Cooper as Charles Aiken
- Abigail Breslin as Jean Fordham
- Benedict Cumberbatch as "Little" Charles Aiken
- Juliette Lewis as Karen Weston
- Margo Martindale as Mattie Fae Aiken
- Dermot Mulroney as Steve Huberbrecht
- Julianne Nicholson as Ivy Weston
- Sam Shepard as Beverly Weston
- Misty Upham as Johnna Monevata