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- Salma Hayek as Sara Sandoval
- Penelope Cruz as Maria Alvarez
- Steve Zahn as Quentin Cooke
- Dwight Yoakam as Tyler Jackson
- Jose Maria Negri as Padre Pablo
- Audra Blaser as Clarissa Ashe
- Sam Shepard as Bill Buck
- Ismael 'East' Carlo as Don Diego Sandoval
- Gary Carlos Cervantes as Pedro
- Yomo Tlazotlalli as Gordo