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- Sharon Stone as Catherine Tramell
- David Morrissey as Dr. Michael Glass
- Flora Montgomery as Michelle Broadwin
- Charlotte Rampling as Dr. Milena Gardosh
- David Thewlis as Roy Washburn
- Heathcote Williams as Dr. Jakob Gerst
- Hugh Dancy as Adam Towers
- Indira Varma as Denise Glass
- Anne Caillon as Laney Ward
- Iain Robertson as Peter Ristedes
- Stan Collymore as Kevin Franks
- Kata Dobo as Magda
- Jan Chappell as Angela