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- Charles Grodin as George Newton
- Bonnie Hunt as Alice Newton
- Dean Jones as Dr. Varnick
- Nicholle Tom as Ryce
- Christopher Castile as Ted
- Sarah Rose Karr as Emily
- Oliver Platt as Harvey
- Stanley Tucci as Vernon
- David Duchovny as Brad
- Patricia Heaton as Brie
- Laurel Cronin as Devonia Peet
- Nancy Fish as Miss Grundel