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- Philip Seymour Hoffman as Andy Hanson
- Ethan Hawke as Hank Hanson
- Albert Finney as Charles Hanson
- Marisa Tomei as Gina Hanson
- Rosemary Harris as Nanette Hanson
- Brian F. O'Byrne as Bobby Lasorda
- Aleksa Palladino as Chris Lasorda
- Michael Shannon as Dex
- Amy Ryan as Martha Hanson
- Sarah Livingston as Danielle Hanson