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- Johnny Depp as Sam
- Mary Stuart Masterson as Juniper 'Joon' Pearl
- Aidan Quinn as Benjamin 'Benny' Pearl
- William H. Macy as Randy Burch
- Julianne Moore as Ruthie
- Oliver Platt as Eric
- C.C.H. Pounder as Dr. Garvey
- Dan Hedaya as Thomas
- Joe Grifasi as Mike
- Lynette Walden as Female Customer