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- Dennis Quaid as Lieutenant Remy McSwain
- Ellen Barkin as Anne Osborne
- Ned Beatty as Jack Kellom
- John Goodman as Sergeant Andre DeSoto
- Lisa Jane Persky as Detective McCabe
- Tom O'Brien as Bobby McSwain
- Charles Ludlam as Lamar Parmentel
- Grace Zabriskie as Mam
- Marc Lawrence as Vinnie 'The Cannon' DiMotti
- Solomon Burke as Daddy Mention
- Gailard Sartain as Chef Paul
- Jim Garrison as Judge Jim Garrison
- Ebbe Roe Smith as Ed Dodge