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- David Schwimmer as Charlie
- Simon Pegg as Gus
- Alice Eve as Josie
- Natascha McElhone as Penelope Wood
- Jon Polito as Agent Hymes
- Mimi Rogers as Mrs. Smalls
- Billy Asher Rosenfeld as Deputy Garman
- Julian Glover as 80 Year Old Blind Man
- Olivia Peterson as Emily
- Sarah Edmondson as Isabella
- Shauna Shim as Melanie #1
- Laurence Bouvard as Melanie #2
- Mindy Lee Raskin as Melanie #3