The line between what we know as reality and fantasy has fallen. Outed by the vampires he once hunted as a delusional serial murderer who believes he is a vampire hunter; Blade is on the run from the very humans he once protected.
Meanwhile, having their ranks decimated thanks to Blade; the vampire ruling caste has sought out their ancestor to restore them to their former glory. He is the First Vampire, the Forerunner to Them All ... Dracula.
But Blade won't be facing this new array of enemies alone. Accompanied by the Nightstalkers, a ragtag team of vampire hunters who believe that this is not their final stand but their hope for absolute victory.
- Wesley Snipes as Blade
- Kris Kristofferson as Abraham Whistler
- Jessica Biel as Abigail Whistler
- Ryan Reynolds as Hannibal King
- Dominic Purcell as Dracula
- Parker Posey as Danica Talos
- Callum Keith Rennie as Asher Talos
- Triple H as Jarko Grimwood
- Natasha Lyonne as Sommerfield
- Haili Page as Zoey Sommerfield
- John Michael Higgins as Dr. Edgar Vance
- Mark Berry as Martin Vreede
- Patton Oswalt as Hedges
- James Remar as Ray Cumberland
- Michael Rawlins as Wilson Hale
- Eric Bogosian as Bentley Tittle
- Christopher Heyerdahl as Caulder