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- Kenny Everett as Dr. Lukas Mandeville
- Pamela Stephenson as Dr. Barbara Coyle
- Vincent Price as Sinister Man
- Gareth Hunt as Elliot Broome
- Don Warrington as Stephen Wilson
- John Fortune as John Harrison
- Sheila Steafel as Sheila Finch
- John Stephen Hill as Henry Noland
- Cleo Rocos as Deborah Kedding
- Graham Stark as The Blind Man
- Pat Ashton as Barmaid
- David Lodge as Inspector Goule
- Debbie Linden as Attractive Girl
- Tim Barrett as Doctor
- Barry Cryer as Police Inspector
- Anna Dawson as Nurse
- Michael McIntyre as E.T.