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- Madonna as Rebecca Carlson
- Willem Dafoe as Frank Dulaney
- Joe Mantegna as Robert Garrett
- Anne Archer as Joanne Braslow
- Julianne Moore as Sharon Dulaney
- Stan Shaw as Charles Briggs
- Charles Hallahan as Dr. McCurdy
- Lillian Lehman as Judge Burnham
- Mark Rolston as Detective Reese
- Jeff Perry as Gabe
- Richard Riehle as Detective Griffin
- Jurgen Prochnow as Dr. Alan Payley
- Frank Langella as Jeffrey Roston