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- Whoopi Goldberg as Jane DeLuca
- Mary-Louise Parker as Robin Nickerson
- Drew Barrymore as Holly Pulchik
- Matthew McConaughey as Abe Lincoln
- James Remar as Alex
- Billy Wirth as Nick
- Anita Gillette as Elaine Nickerson
- Dennis Boutsikaris as Massarelli
- Estelle Parsons as Louise
- Amy Aquino as Anna