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- Will Ferrell as Camden "Cam" Brady
- Zach Galifianakis as Martin Sylvester "Marty" Huggins
- Jason Sudeikis as Mitch Wilson
- Katherine LaNasa as Rose Brady
- Dylan McDermott as Tim Wattley
- John Lithgow as Glenn Motch
- Dan Aykroyd as Wade Motch
- Brian Cox as Raymond Huggins
- Sarah Baker as Mitzi Huggins
- Grant Goodman as Clay Huggins
- Kya Haywood as Dylan Huggins
- Karen Maruyama as Mrs. Yao
- Taryn Terrell as Janette
- Josh Lawson as Tripp Huggins
- Tzi Ma as Mr. Zheng
- Jack McBrayer as Mr. Mendenhall
- Kate Lang Johnson as Shana St. Croix
- Steve Tom as Ben Langley
- John Goodman as Scott Talley