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- Drew Barrymore as Amanda
- James Woods as Dick Morrison
- Candy Clark as Sally Ann
- Alan King as Dr. Vinny Donatti
- Robert Hays as Johnny Norris
- Kenneth McMillan as Cressner
- James Naughton as Hugh
- James Rebhorn as Drunk Businessman
- Charles S. Dutton as Dom
- Mike Starr as Ducky
- Frank Welker as Cat (voice) and Troll (voice)