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- Clifton Webb as Frank Bunker Gilbreth
- Jeanne Crain as Ann Gilbreth
- Myrna Loy as Mrs. Lillian Gilbreth
- Betty Lynn as Deborah Lancaster
- Edgar Buchanan as Dr. Burton
- Barbara Bates as Ernestine Gilbreth
- Mildred Natwick as Mrs. Mebane
- Sara Allgood as Mrs. Monahan
- Jimmy Hunt as William Gilbreth
- Carol Nugent as Lillie Gilbreth
- Norman Ollestad as Frank Gilbreth Jr.
- Evelyn Varden as School Principal
- Craig Hill as Tom Black
- Patti Brady as Martha Gilbreth
- Teddy Driver as Dan Gilbreth
- Roddy McCaskill as Jack Gilbreth
- Judy Ann Whaley as Baby Denise