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- Laura Dern as Ruth Stoops
- Swoosie Kurtz as Diane Siegler
- Kurtwood Smith as Norm Stoney
- Mary Kay Place as Gail Stoney
- Kelly Preston as Rachel
- M.C. Gainey as Harlan
- Kenneth Mars as Dr. Charles Rollins
- David Graf as Judge Richter
- Kathleen Noone as Nurse Pat
- Tippi Hedren as Jessica Weiss
- Burt Reynolds as Blaine Gibbons
- Alicia Witt as Cheryl Stoney
- Diane Ladd as Ruth's Mother