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- Rufus Sewell as John Murdoch
- William Hurt as Inspector Frank Bumstead
- Kiefer Sutherland as Dr. Daniel P. Schreber
- Jennifer Connelly as Emma Murdoch
- Richard O'Brien as Mr. Hand
- Ian Richardson as Mr. Book
- Bruce Spence as Mr. Wall
- Colin Friels as Det. Eddie Walenski
- John Bluthal as Karl Harris
- Melissa George as May
- Ritchie Singer as Hotel Manager
- Nicholas Bell as Mr. Rain
- David Wenham as Schreber's Assistant