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- Thomas Jane as Carter Blake
- Saffron Burrows as Dr. Susan McAlester
- Samuel L. Jackson as Russell Franklin
- Jacqueline McKenzie as Janice Higgins
- Michael Rapaport as Tom Scoggins
- Stellan Skarsgard as Jim Whitlock
- LL Cool J as Sherman "Preacher" Dudley
- Aida Turturro as Brenda Kerns