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- Denzel Washington as Special Agent Douglas Carlin
- Val Kilmer as Special Agent Paul Pryzwarra
- Bruce Greenwood as Special Agent Jack McCready
- Jim Caviezel as Carroll Oerstadt
- Matt Craven as Special Agent Larry Minuti
- Paula Patton as Claire Kuchever
- Adam Goldberg as Dr. Alexander Denny
- Elden Henson as Gunnars
- Erika Alexander as Shanti
- Elle Fanning as Abbey
- Donna W. Scott as Beth