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- Rosanna Arquette as Roberta Glass
- Madonna as Susan Thomas
- Aidan Quinn as Dez
- Mark Blum as Gary Glass
- Robert Joy as Jim
- Laurie Metcalf as Leslie Glass
- Anna Levine as Crystal
- Will Patton as Wayne Nolan
- Peter Maloney as Ian
- Steven Wright as Larry Stillman D.D.S.
- John Turturro as Ray
- Anne Carlisle as Victoria
- Richard Hell as Bruce Meeker
- Victor Argo as Sgt. Taskal