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- Renee Zellweger as Barbara Novak
- Ewan McGregor as Catcher Block
- Sarah Paulson as Vikki Hiller
- David Hyde Pierce as Peter "Mac" MacMannus
- Rachel Dratch as Gladys
- Jack Plotnick as Maurice
- Tony Randall as Theodore Banner
- John Aylward as E.G.
- Warren Munson as C.B.
- Matt Ross as J.B.
- Michael Ensign as J.R.
- Timothy Omundson as R.J.
- Ivana Milicevic as Yvette
- Melissa George as Elkie