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- Dennis Quaid as Alex Gardner
- Max von Sydow as Dr. Paul Novotny
- Christopher Plummer as Bob Blair
- David Patrick Kelly as Tommy Ray Glatman
- Kate Capshaw as Jane DeVries
- George Wendt as Charlie Prince
- Eddie Albert as The President
- Chris Mulkey as Gary Finch
- Larry Gelman as Mr. Webber
- Cory “Bumper” Yothers as Buddy
- Redmond Gleeson as Snead
- Eric Gold as Tommy Ray's Father
- Peter Jason as Roy Babcock