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- Penelope Cruz as Consuela Castillo
- Ben Kingsley as David Kepesh
- Dennis Hopper as George O'Hearn
- Patricia Clarkson as Carolyn
- Peter Sarsgaard as Kenneth Kepesh
- Deborah Harry as Amy O'Hearn
- Charlie Rose as Charlie Rose
- Antonio Cupo as Younger Man
- Michelle Harrison as 2nd Student
- Sonja Bennett as Beth
- Chelah Horsdal as Susan Reese