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- Brendan Fraser as John Crowley
- Harrison Ford as Dr. Robert Stonehill
- Keri Russell as Aileen Crowley
- Courtney B. Vance as Marcus Temple
- Meredith Droeger as Megan Crowley
- Diego Velazquez as Patrick Crowley
- Sam M. Hall as John Crowley, Jr.
- Patrick Bauchau as Eric Loring
- Jared Harris as Dr. Kent Webber
- Alan Ruck as Pete Sutphen
- David Clennon as Dr. Renzler
- Dee Wallace as Sal
- Ayanna Berkshire as Wendy Temple
- P.J. Byrne as Dr. Preston
- Andrea White as Dr. Allegria
- G.J. Echternkamp as Niles
- Vu Pham as Vinh Tran
- Derek Webster as Cal Dunning