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- Ewan McGregor as Stephen Wilson
- Ashley Judd as Joanna Eris
- Patrick Bergin as Alexander Leonard
- Genevieve Bujold as Dr. Jeanne Brault
- Jason Priestly as Gary
- K.D. Lang as Hilary
- David Nerman as Mickey Argyle
- Jeanine Thierault as Nathy
- Don Jordan as Toohey