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- Dennis Quaid as Captain Frank Towns
- Giovanni Ribisi as Elliott
- Tyrese Gibson as A.J.
- Miranda Otto as Kelly Johnson
- Tony Curran as Alex Rodney
- Hugh Laurie as Ian
- Scott Michael Campbell as James Liddle
- Sticky Fingaz as Jeremy
- Jacob Vargas as Sammi
- Kevork Malikyan as Rady
- Paul Ditchfield as Dr. Gerber
- Martin Hindy as Newman
- Jared Padalecki as John Davis
- Bob Brown as Kyle
- Anthony Wong as Lead Smuggler