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- Milla Jovovich as Dr. Abigail "Abbey" Tyler
- Charlotte Milchard as The 'Real' Dr. Abigail Tyler
- Elias Koteas as Dr. Abel Campos
- Will Patton as Sheriff August
- Corey Johnson as Tommy Fisher
- Hakeem Kae-Kazim as Awolowa Odusami
- Enzo Cilenti as Scott Stracinsky
- Eric Loren as Deputy Ryan
- Raphael Coleman as Ronnie Tyler
- Mia Mckenna-Bruce as Ashley Tyler
- Olatunde Osunsanmi as "Director" Olatunde Osunsanmi