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- Vince Vaughn as Frederick "Fred" Claus
- Paul Giamatti as Nicholas "Nick" Claus
- Miranda Richardson as Mrs. Annette Claus
- Kathy Bates as Mother Claus
- Trevor Peacock as Father Claus
- Rachel Weisz as Wanda Blinkowski
- John Michael Higgins as Willy
- Kevin Spacey as Clyde Northcutt
- Elizabeth Banks as Charlene
- Bobb'e J. Thompson as Samuel "Slam" Gibbons
- Chris 'Ludacris' Bridges as DJ Donnie