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- Patrick Swayze as Sam Wheat
- Demi Moore as Molly Jensen
- Whoopi Goldberg as Oda Mae Brown
- Tony Goldwyn as Carl Bruner
- Rick Aviles as Willie Lopez
- Vincent Schiavelli as Subway Ghost
- Gail Boggs as Oda Mae's Sister
- Armelia McQueen as Oda Mae's Sister
- Phil Leeds as Hospital Ghost
- Augie Blunt as Orlando
- Sharon Breslau as Cemetery Ghost
- Vivian Bonnell as Ortisha
- Bruce Jarchow as Lyle Furgeson