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- Ricky Gervais as Bertram Pincus
- Tea Leoni as Gwen
- Greg Kinnear as Frank Herlihy
- Aasif Mandvi as Dr. Prashar
- Billy Campbell as Richard
- Alan Ruck as Ghost of a Family Man
- Kristen Wiig as Bertram's Surgeon
- Brian d'Arcy James as Irish Eddie
- Jeff Hiller as a Naked Ghost
- Michael-Leon Wooley as Medical Attorney
- Aaron Tveit as The Anesthesiologist
- Bridget Moloney as The Receptionist