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- Meg Ryan as Eve Mozell Marks
- Diane Keaton as Georgia Mozell
- Lisa Kudrow as Maddy Mozell
- Walter Matthau as Lou Mozell
- Adam Arkin as Joe Marks
- Cloris Leachman as Pat Mozell
- Jesse James as Jesse Marks
- Edie McClurg as Esther
- Katie Stratton as Young Georgia Mozell
- Shaun Duke as Dr. Omar Kunundar
- Ann Bortolotti as Ogmed Kunundar