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- Bradley Cooper as Phil Wenneck
- Ed Helms as Dr. Stu Price
- Zach Galifianakis as Alan Garner
- Justin Bartha as Doug Billings
- Heather Graham as Jade
- Jeffrey Tambor as Sid Garner
- Sasha Barrese as Tracy Garner
- Rachael Harris as Melissa
- Ken Jeong as Leslie Chow
- Mike Epps as Black Doug
- Rob Riggle as Officer Franklin
- Cleo King as Officer Garden
- Mike Tyson as Himself
- Murray Gershenz as Felix
- Andrew Astor as Eli
- Nathalie Fay as Lisa
- Gillian Vigman as Stephanie
- Sondra Currie as Linda