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- Bradley Cooper as Phil Wenneck
- Ed Helms as Dr. Stuart "Stu" Price
- Zach Galifianakis as Alan Garner
- Justin Bartha as Doug Billings
- Ken Jeong as Leslie Chow
- Jeffrey Tambor as Sid Garner
- Jamie Chung as Lauren
- Bryan Callen as Samir
- Mason Lee as Teddy
- Paul Giamatti as Kingsley
- Sasha Barrese as Tracy Billings
- Gillian Vigman as Stephanie Wenneck
- Yasmin Lee as Kimmy
- Nirut Sirijanya as Fong