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- Ben Affleck as Neil
- Jennifer Aniston as Beth Murphy
- Drew Barrymore as Mary Harris
- Jennifer Connelly as Janine Gunders
- Kevin Connolly as Conor Barry
- Bradley Cooper as Ben Gunders
- Ginnifer Goodwin as Gigi Phillips
- Scarlett Johansson as Anna Marks
- Justin Long as Alex
- Kris Kristofferson as Rod Murphy
- Hedy Burress as Laura
- Busy Philipps as Kelli Ann
- Leonardo Nam as Joshua Nguyen
- Rod Keller as Bruce
- Morgan Lily as Little Girl
- Natasha Leggero as Amber Gnech
- Cory Hardrict as Tyrone
- Sasha Alexander as Catharine
- Angela V. Shelton as Angela
- John Ross Bowie as Dan the Wiccan