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- Mel Brooks as Dr. Richard Harpo Thorndyke
- Madeline Kahn as Victoria Brisbane
- Ron Carey as Brophy
- Cloris Leachman as Nurse Diesel
- Harvey Korman as Dr. Montague
- Howard Morris as Professor Lilloman
- Albert Whitlock as Arthur Brisbane
- Rudy De Luca as Braces
- Dick Van Patten as Dr. Wentworth
- Barry Levinson as Dennis
- Ron Clark as Zachary Cartwright