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- Christopher Lambert as Connor MacLeod
- Mario Van Peebles as Kane
- Deborah Kara Unger as Dr. Alexandra Johnson
- Martin Neufeld as Lt. John Stenn
- Mako Iwamatsu as Nakano
- Raoul Trujillo as Senghi Khan
- Jean-Pierre Perusse as Khabul Khan
- Daniel Do as Dr. Fuji Takamura
- Gabriel Kakon as John MacLeod
- Louis Bertignac as Pierre Bouchet
- Michael Jayston as Jack Donovan