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- Thora Birch as Elizabeth 'Liz' Dunn
- Keira Knightley as Frances 'Frankie' Almond Smith
- Desmond Harrington as Michael 'Mike' Steel
- Laurence Fox as Geoffrey 'Geoff' Bingham
- Daniel Brocklebank as Martyn Taylor
- Embeth Davidtz as Dr. Philippa Horwood
- Steven Waddington as DCS Tom Howard
- Kelly Hunter as DI Chapman
- Anastasia Hille as Forensic Pathologist Gillian