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- Rick Moranis as Wayne Szalinski
- Marcia Strassman as Diane Szalinski
- Robert Oliveri as Nick Szalinski
- John Shea as Dr. Charles Hendrickson
- Lloyd Bridges as Clifford Sterling
- Keri Russell as Mandy Park
- Amy O'Neill as Amy Szalinski
- Ron Canada as Marshall Brooks
- Daniel Shalikar as Adam Szalinski
- Joshua Shalikar as Adam Szalinski
- Gregory Sierra as Terence Wheeler
- Michael Milhoan as Captain Ed Myerson
- Leslie Neale as Constance Winters