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- James Marsden as Fred O'Hare
- Russell Brand as E.B.
- Kaley Cuoco as Samantha "Sam" O'Hare
- Hank Azaria as Carlos and Phil
- Gary Cole as Henry O'Hare
- Elizabeth Perkins as Bonnie O'Hare
- Hugh Laurie as E.B.'s Dad
- Tiffany Espensen as Alex O'Hare
- Chelsea Handler as Mrs. Beck