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- Daniel Radcliffe as Ignatius "Ig" Perrish
- Juno Temple as Merrin Williams
- James Remar as Derrick Perrish
- Kelli Garner as Glenna
- Heather Graham as The Waitress
- Joe Anderson as Terry Perrish
- Max Minghella as Lee Tourneau
- Laine MacNeil as Young Glenna
- Sabrina Carpenter as Young Merrin
- Alex Zahara as Dr. Renald
- Kendra Anderson as Delilah
- Michael Adamthwaite as Eric Hannity
- Desiree Zurowski as Radio Reporter