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- Sarah Jessica Parker as Kate Reddy
- Pierce Brosnan as Jack Abelhammer
- Greg Kinnear as Richard Reddy
- Busy Philipps as Wendy Best
- Olivia Munn as Momo Hahn
- Christina Hendricks as Allison Henderson
- Emma Rayne Lyle as Emily Reddy
- Kelsey Grammer as Clark Cooper
- Jessica Szohr as Paula
- Seth Meyers as Chris Bunce
- Jane Curtin as Marla Reddy
- Sarah Shahi as Janine LoPietro
- Leslie Guzman as Lola Laughningle