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- Brendan Fraser as Prof. Trevor 'Trev' Anderson
- Josh Hutcherson as Sean Anderson
- Anita Briem as Hannah Asgeirsson
- Seth Meyers as Professor Alan Kitzens
- Jean-Michel Pare as Maxwell 'Max' Anderson
- Jane Wheeler as Elizabeth 'Liz' Anderson
- Giancarlo Caltabiano as Leonard
- Garth Gilker as Sigurbjorn Asgeirsson
- Kaniehtiio Horn